Exosome therapy can not only reduce or eliminate plaque buildup in the penis but also strengthen the surrounding tissue.
When men with Peyronie’s come to our doctor they are upset since they spoke to urologists and neurologists say all there for treatment is Xiaflex or penile surgery. Our clinic is a kind of their last resort and we’re explaining to them that exosome + PRP shots can help their Peyronie’s disease symptoms.
A question that patients usually ask is about our success rate and will Peyronie’s come back after the treatment, and how much time is needed to cure it. Actually, exosomes refer to regenerative medicine and are successfully applied for the treatment of back pain in a very short time. Some exosomes persist in a body for a month, others for a week, but they change the milieu in the body and this will ultimately become a permanent change.
Exosomes contain a protein called TGFB3 which comes from the bone marrow and is used as an anti-inflammatory supplement. Inflammatory CD4+ T cells turn into regulatory non-inflammatory tissues and stop the inflammatory process unless some other inflammatory insult comes up that T cell that was causing inflammation, it is going to stay off and you are going to see the immediate recovery brought by exosomes.
The recovery comes from the proteins and you will see a more drawn-out effect from 6 weeks to 4 months. Even a month already gives a secondary wave of regeneration since exosomes change the way the cells act thus defining their behavior and changing it from illness to recovery.
Exosomes for Peyronie’s Disease Effects
Exosome therapy can not only reduce or eliminate plaque buildup in the penis but also strengthen the surrounding cells and tissue resulting in optimal penile rejuvenation. This can:
- increase sensitivity and pleasure;
- improve sexual performance;
- straighten curvature;
- increase penis size or girth.
This therapy is used to treat many disorders due to its unique nature in transforming into required cells while promoting others into action. A safe, simple procedure that has already undergone many studies to determine its effectiveness in treating symptoms of Peyronie’s Disease.
With exosome therapy, you’ll be able to recognize dramatic improvements that will help boost your self-esteem and restore function and confidence to your life!
The Power of Exosomes
A lot of people assume that exosomes are stem cells – but they are not. Exosomes are defined as very small extracellular vesicles which are produced and released from most mammalian cells. Vesicles are delimited particles that have a lipid bilayer around them to protect the cargo it is carrying. A simple way to imagine them is by thinking of little lipid bubbles that contain small molecules.
The purpose of exosomes is to transport molecules between the cell and its surrounding. In other words, the cell releases exosomes to communicate with other cells and tissues. Through exosomes, cells can manage physiological processes like coagulation, intercellular signaling, and waste management.
Exosomes are present in biological fluids like blood and urine, and can also be found in tissues.
How were exosomes discovered?
Exosomes were first discovered in 1983 in immature red blood cells by Stahl and his team¹ as well as Johnstone et al. in the same year. The term “exosome” was coined by Johnstone a few years later.
These studies showed that intra-luminal vesicles (ILVs) generated in multi-vesicular bodies can be released to the space outside the cell through fusion with the plasma membrane.
These insights, though impressive, did not spark much interest in exosomes within the scientific world for a few decades. It was not until the early 2000s that the potential of exosomes was recognized, which is evident when looking at the significant increase in publications (115 publications in 2006, 1010 publications in 2015).
What can exosomes carry?
Exosome content can be proteins, lipids, and nucleic acids. The content of exosomes is not only cell-type-specific but also influenced by the condition of the cell. This means that depending on the health and current status of the cell, it will release different types of cargo into extracellular space.
One outstanding property of exosomes is that they can mediate regenerative outcomes after injuries or during acute phases of a disease if they are released from stem cells. Exosomes from mesenchymal stem cells, for instance, were found to activate several signaling pathways which are important in bone fracture repair and wound healing. These exosomes also participate in the regulation of immune-mediated responses and inflammatory diseases.
Exosomes have also been known to contain numerous disease-associated cargos, because they can be released from sources such as cancer cells, or carry neurodegenerative associated peptides. However, the mechanisms by which disease-associated factors spread between cells still remain poorly understood.
What is the difference between exosomes and extracellular vesicles?
Are exosomes extracellular vesicles? Or are they two different things?
Exosomes are in fact a subtype of extracellular vesicles (EVs). EVs are generally defined as membrane-bound particles which are released from almost all known cells. They contain cargo and cannot replicate. EV sizes range from 20nm to 10µm; however, the majority of EVs are smaller than 200nm.
The release of exosomes from the cell is via so-called multivesicular bodies, which fuse with the cell surface, the outer cell membrane, and set the vesicles free. The size of exosomes is limited by that of the parent multivesicular body. Because of this, exosomes are generally smaller than most other EVs, with a typical diameter range from 30 to 150nm.
EVs have a variety of biological functions, such as elimination of unwanted materials, transfer of functional proteins and RNA, molecular recycling, communication with other cells, and others.
Besides exosomes, there are other types of EVs, such as apoptotic bodies and ectosomes. They are derived from cells undergoing apoptosis and plasma membrane shedding and thus have different functions.
If you need to get more information concerning exosomes and their healing possibilities please get in touch with us here.